Two ingredients dominate skincare feeds in 2026: PDRN — often labelled “salmon DNA” — and azelaic acid. Both are genuinely useful, but the marketing around them is loud. Here's a plain-English look at what each does, who should use it, and how to avoid irritation.
What is PDRN?
PDRN (polydeoxyribonucleotide) is a fragment of DNA, most commonly sourced from salmon, used in skincare for its repairing and skin-plumping reputation. In topical serums it's paired with peptides and humectants to support a firmer, more hydrated look and smoother texture over time.
What to realistically expect: better hydration, a plumper surface, and gradual smoothing with consistent use — not an overnight transformation. Treat it as a supportive anti-aging step, not a medical treatment.
Who is PDRN for?
It suits most skin types, including dry and mature skin that wants a firmer, glowier finish. Because it's hydration-focused rather than exfoliating, it's usually gentle. A firming PDRN serum layers on after cleansing and before moisturizer.
What is azelaic acid?
Azelaic acid is a gentle acid that works on tone and clarity. It helps fade the dark marks left behind by blemishes, calms redness, and refines rough texture — without the sting many stronger acids cause. That combination makes it a favourite for sensitive and blemish-prone skin.
How to use azelaic acid without irritation
- Apply to clean, dry skin — a thin layer is enough.
- Start 3–4 times a week, then build to daily as skin adjusts.
- Follow with a calming moisturizer to buffer.
- Use SPF in the morning; fading ingredients work best against a backdrop of sun protection.
A formula built for reactive skin, like this azelaic acid cream for sensitive skin, makes the “start slow” approach easy.
Can you use PDRN and azelaic acid together?
Yes — they solve different problems and pair nicely. A practical split: azelaic acid for tone and blemishes as your treatment step, and a PDRN serum for firmness and hydration on top. If your skin is easily irritated, alternate nights until you know how it responds.
Frequently asked questions
Is “salmon DNA” safe?
Topically, PDRN is well tolerated by most people. As with any new active, patch test first.
Will azelaic acid make me purge?
It's gentler than most actives and rarely causes heavy purging. If you see mild adjustment, ease the frequency rather than stopping entirely.
How long until I see results?
Tone and texture changes typically show over 6–8 weeks of consistent use. Hydration and plumpness from PDRN can look better much sooner.
Try them for yourself
Explore both in the Beauty & Personal Care collection, or start with the Firming PDRN Serum and Azelaic Acid Cream.